Acute Kidney Injury (AKI): Diagnostic approach

A spike in serum creatinine and/or a decrease in urine output have typically been used to diagnose AKI. From the Risk, Injury, Failure, Loss, End-stage (RIFLE) criteria in 2004 to the AKI Network (AKIN) categorization in 2007 [4, 5], the definition has developed. Both were integrated in 2012, resulting in the KDIGO (Kidney Disease Improving Global Outcomes) classification. AKI is defined as a spike in serum creatinine of 0.3 mg/dl (26.5 mol/l) or more in 48 hours or a rise of at least 1.5-fold f...